Mario Losen Selected Research

Proteasome Inhibitors

12/2012	Targeting plasma cells with proteasome inhibitors: possible roles in treating myasthenia gravis?
2/2011	Proteasome inhibition with bortezomib depletes plasma cells and autoantibodies in experimental autoimmune myasthenia gravis.

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Mario Losen Research Topics

Disease

27	Myasthenia Gravis 01/2024 - 10/2005
10	Autoimmune Diseases (Autoimmune Disease) 01/2017 - 02/2007
8	Experimental Autoimmune Myasthenia Gravis (Autoimmune Experimental Myasthenia Gravis) 08/2015 - 10/2005
7	Alzheimer Disease (Alzheimer's Disease) 08/2022 - 01/2017
6	Muscle Weakness 07/2022 - 08/2010
5	Neoplasms (Cancer) 01/2019 - 11/2010
4	Psychotic Disorders (Schizoaffective Disorder) 01/2021 - 04/2016
3	Encephalitis (Encephalitis, Rasmussen) 01/2023 - 01/2017
3	Autoimmune Diseases of the Nervous System 01/2022 - 09/2019
3	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021 - 10/2009
3	Schizophrenia (Dementia Praecox) 01/2018 - 09/2013
2	Epilepsy (Aura) 01/2023 - 01/2022
2	Nervous System Diseases (Neurological Disorders) 01/2023 - 09/2013
2	Inflammation (Inflammations) 08/2022 - 01/2021
2	Limbic Encephalitis (Paraneoplastic Limbic Encephalitis) 01/2022 - 09/2013
2	Amyloid Plaque 01/2021 - 04/2012
2	Mental Disorders (Mental Disorder) 09/2019 - 01/2017
2	Bipolar Disorder (Manic Depressive Psychosis) 01/2018 - 01/2017
2	Multiple Myeloma 08/2014 - 12/2012
2	Channelopathies 08/2014 - 09/2013
1	Cognitive Dysfunction 07/2023
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2023
1	Neuroinflammatory Diseases 01/2021
1	Neuroblastoma 01/2021
1	Brain Diseases (Brain Disorder) 01/2020
1	Hashimoto's encephalitis 01/2020
1	Neurologic Manifestations (Neurological Manifestations) 09/2019
1	Thymoma (Thymic Carcinoma) 01/2019
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2018
1	Wounds and Injuries (Trauma) 01/2018
1	Arthrogryposis 10/2017
1	Rhabdomyosarcoma 10/2017
1	Hypertrophy 07/2017
1	Central Nervous System Diseases (CNS Diseases) 01/2017
1	Autistic Disorder (Autism) 04/2016
1	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 04/2016
1	Carcinogenesis 02/2016

Drug/Important Bio-Agent (IBA)

28	AutoantibodiesIBA 01/2024 - 10/2005
18	AntibodiesIBA 01/2023 - 02/2007
17	Cholinergic ReceptorsIBA 07/2022 - 10/2005
13	Proteins (Proteins, Gene)FDA Link 01/2021 - 02/2007
9	Immunoglobulin G (IgG)IBA 01/2024 - 09/2007
9	muskIBA 01/2024 - 10/2009
8	CeramidesIBA 07/2023 - 10/2009
7	Phosphotransferases (Kinase)IBA 01/2024 - 04/2012
7	AntigensIBA 01/2021 - 08/2010
6	SphingolipidsIBA 08/2022 - 01/2020
3	Biomarkers (Surrogate Marker)IBA 07/2023 - 02/2016
3	Amyloid (Amyloid Fibrils)IBA 08/2022 - 11/2020
3	ApolipoproteinsIBA 08/2022 - 11/2020
3	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 07/2022 - 11/2009
3	Complement System Proteins (Complement)IBA 01/2018 - 12/2013
3	Acetylcholine (Acetylcholine Chloride)FDA Link 01/2017 - 11/2009
3	Bortezomib (Velcade)FDA Link 08/2014 - 02/2011
2	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 08/2022 - 01/2021
2	Apolipoprotein E4IBA 08/2022 - 11/2020
2	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 01/2019
2	Ion Channels (Ion Channel)IBA 09/2019 - 09/2013
2	EpitopesIBA 01/2018 - 01/2017
2	Monoclonal AntibodiesIBA 10/2017 - 01/2017
2	Therapeutic UsesIBA 09/2015 - 02/2011
2	Proteasome Endopeptidase Complex (Proteasome)IBA 08/2014 - 02/2011
2	CollagenIBA 01/2014 - 06/2010
2	AutoantigensIBA 08/2013 - 02/2007
2	Proteasome InhibitorsIBA 12/2012 - 02/2011
2	Carrier Proteins (Binding Protein)IBA 04/2012 - 11/2009
2	peripheral membrane protein 43KIBA 02/2007 - 10/2005
1	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2024
1	anti-GAD65 autoantibodyIBA 01/2023
1	Protein Isoforms (Isoforms)IBA 08/2022
1	Fingolimod Hydrochloride (FTY720)FDA Link 08/2022
1	metabotropic glutamate receptor type 1IBA 01/2022
1	Apolipoproteins E (ApoE)IBA 01/2021
1	Cardiolipins (Cardiolipin)IBA 01/2021
1	Glutamate Decarboxylase (Decarboxylase, Glutamate)IBA 01/2021
1	SphingomyelinsIBA 01/2021
1	Nuclear Antigens (Extractable Nuclear Antigens)IBA 01/2021
1	N- (3- hydroxy- 1- hydroxymethyl- 3- phenylpropyl)dodecanamideIBA 11/2020
1	Intravenous Immunoglobulins (IVIG)FDA Link 01/2020
1	Surface Antigens (Surface Antigen)IBA 01/2020
1	Neurotransmitter Agents (Neurotransmitter)IBA 09/2019
1	Membrane Proteins (Integral Membrane Proteins)IBA 01/2019
1	RNA (Ribonucleic Acid)IBA 01/2019
1	Paclitaxel (Taxol)FDA LinkGeneric 01/2018
1	Cisplatin (Platino)FDA LinkGeneric 01/2018
1	Fc Receptors (Fc Receptor)IBA 01/2018
1	CytokinesIBA 01/2018
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2018
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2018
1	Pemetrexed (MTA)FDA Link 01/2018
1	InterleukinsIBA 01/2018
1	CrizotinibIBA 01/2018
1	BMS-906024IBA 01/2018
1	Etoposide (VP 16)FDA LinkGeneric 01/2018
1	Indicators and Reagents (Reagents)IBA 10/2017
1	Neurotransmitter Receptors (Neurotransmitter Receptor)IBA 01/2017
1	cyanine dye 5IBA 02/2016
1	GelatinIBA 02/2016
1	Matrix Metalloproteinase 2 (Gelatinase A)IBA 02/2016

Therapy/Procedure

6	Therapeutics 01/2024 - 11/2010